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Tropolone 环庚三烯酚酮

规格: 98%

CAS: 533-75-5

产品编号: H89337

MDL: MFCD00004158

品牌: INFI

Chemical Name	2-Hydroxycyclohepta-2,4,6-trienone
Synonym	2,4,6-Cycloheptatrien-1-one, 2-hydroxy- 2-HYDROXY-2,4,6-CYCLOHEPTATRIEN-1-ONE 2-Hydroxy-2,4,6-Cycloheptatrie 2-Hydroxy-2,4,6-cycloheptatrien-1-one 2-Hydroxy-2,4,6-cycloheptatrienone 2-Hydroxy-2,4,6-cycloheptatrienone; 2-Hydroxycyclohepta-2,4,6-trienone 2-Hydroxycyclohepta-2,4,6-trien-1-one 2-Hydroxycyclohepta-2,4,6-trienone 2-Hydroxytropone 2-hydroxycyclohepta-2,4,6-trienone 2-hydroxytropone 2-羟基-2,4,6-环庚三烯-1-酮 6-cycloheptatrien-1-one,2-hydroxy-4 Purpurocatechol TROPOLONE TROPOLONE 99+% Tropolone Tropolone,98% a-Tropolone {} {} {} {} {uni_ha α-Tropolone 【草(之上)+卓】酚酮托酚酮环庚三烯酚酮环庚三烯酚酮/托酚酮草酚酮,托酚酮革酚酮
MDL Number	MFCD00004158
PubChem Substance ID	10789
Beilstein Registry Number	1904978
CAS Number	533-75-5
EC Number	208-577-2
Reaxys-RN	1904978
Chemical Name Translation	环庚三烯酚酮
Wiswesser Line Notation	L7VJ BQ
LabNetwork Molecule ID	LN00193176
InChI	InChI=1S/C7H6O2/c8-6-4-2-1-3-5-7(6)9/h1-5H,(H,8,9)

GHS Symbol

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 106 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   YKKZAJ Yakugaku Zasshi.  Journal of Pharmacy.  (Nippon Yakugakkai, 2-12-15
   Shibuya, Shibuya-ku, Tokyo 150, Japan)  No.1-    1881-
   Volume(issue)/page/year: 92,19,1972

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 190 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   TXCYAC Toxicology.  (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
   Limerick, Ireland) V.1-    1973-  Volume(issue)/page/year: 14,217,1979

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 233 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - analgesia
   Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
   YKKZAJ Yakugaku Zasshi.  Journal of Pharmacy.  (Nippon Yakugakkai, 2-12-15
   Shibuya, Shibuya-ku, Tokyo 150, Japan)  No.1-    1881-
   Volume(issue)/page/year: 91,550,1971

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 212 mg/kg
TOXIC EFFECTS :
   Behavioral - convulsions or effect on seizure threshold
   Behavioral - excitement
   Behavioral - rigidity (including catalepsy)
REFERENCE :
   TXCYAC Toxicology.  (Elsevier Scientific Pub. Ireland, Ltd., POB 85,
   Limerick, Ireland) V.1

RTECS	GU4075000
WGK Germany	3
Personal Protective Equipment	Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
Signal word	Warning
Safety Statements
S22 Do not breathe dust 不要吸入粉尘； S24/25 Avoid contact with skin and eyes 避免皮肤和眼睛接触； S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见； S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
Risk Statements
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Precautionary statements
P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。 P262 Do not get in eyes, on skin, or on clothing. 不要接触眼睛，皮肤或衣服。
Storage condition	2-8℃ 0-10°C Hygroscopic 0-10 2-8°C

医药中间体间。

{MCE} [2]. VardaKahn, et al.Inhibition of mushroom tyrosinase by tropolone Phytochemistry. Volume 24, Issue 5, 1985, Pages 905-908

{ALD} Beilstein: 8,IV,159

{ALFA} Non-benzenoid aromatic system, analogous to phenol. For a review of 7-membered conjugated cyclic systems, see: Chem. Rev., 73, 293 (1973). For a study of the role of chelation and resonance in the intrinsic acidity and basicity of tropolone, see: J. Org. Chem., 62, 3200 (1997).

{ALFA} Reagent for Rh: Mikrochim. Acta, 459 (1972).

{uni_hamburg} Short: II/2

{uni_hamburg} Short: II/24B

{MCE} [1]. Donald D Nolting,et al. Synthesis of bicyclo[5.3.0]azulene derivatives. Nat Protoc. 2009; 4(8): 1113–1117.

{MCE} [2]. VardaKahn, et al.Inhibition of mushroom tyrosinase by tropolone Phytochemistry. Volume 24, Issue 5, 1985, Pages 905-908

化学属性

Mol. Formula	C7H6O2
Mol. Weight	122
Boiling Point	80-84
Melting Point	50-54
Density	1.278
Flash Point	>110°(230°F)
TSCA	No
Stability	易吸潮

*以上化合物性质及应用等信息仅供参考

手性催化剂及配体

合成砌块

医药中间体

Tropolone 环庚三烯酚酮

规格: 98%

化学属性

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