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1-Methyl-2-pyrrolidone 1-甲基-2-吡咯烷酮

规格: 99%, SpcDry, Water≤50 ppm (by K.F.), SpcSeal
CAS: 872-50-4
产品编号: H86968
MDL: MFCD00003193
品牌: INFI
Chemical Name1-Methyl-2-pyrrolidone
CAS Number872-50-4
Alfabeta NameMETHYLPYRROLIDINONE 12---
MDL NumberMFCD00003193
Synonym M-Pyrol N-ME N-Methyl-2-pyrrolidone N-Methylpyrolidon N-methylpyrrolidinone {} {} {Chemicalbook}
PubChem Substance ID354334395
EC Number212-828-1
Beilstein Registry Number106420
Merck Number6117
Reaxys-RN106420
Chemical Name Translation1-甲基-2-吡咯烷酮
Wiswesser Line NotationT5NVTJ A
LabNetwork Molecule IDLN00164397
InChIInChI=1S/C5H9NO/c1-6-4-2-3-5(6)7/h2-4H2,1H3
GHS Symbol
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 80500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 18,922,1987

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2472 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 26,1581,1976

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5130 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EPASR* United States Environmental Protection Agency, Office of Pesticides
   and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW,
   Washington, DC 20460)  History unknown.  Volume(issue)/page/year:
   8EHQ-1087-0695

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 7 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
   Academic Press, Inc., 1969  Volume(issue)/page/year: -,408,1969

TYPE OF TEST            : LD50 - Lethal dose,

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 154 mmol/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   11,31,1988

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 150 ppm/6H
SEX/DURATION            : female 7-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
   Reproductive - Effects on Newborn - delayed effects
REFERENCE :
   NETEEC Neurotoxicology and Teratology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.9-    1987- Volume(issue)/page/year:
   16,241,1994

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 166 mg/kg
SEX/DURATION            : female 9 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   BIRUAA Biologische Rundschau.  (VEB Gustav Fischer Verlag, Postfach 176,
   Jena DDR-6900, Ger. Dem. Rep.)  V.1-    1963-  Volume(issue)/page/year:
   14,38,1976

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 116 ppm/6H
SEX/DURATION            : multigenerations
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   DCTODJ Drug and Chemical Toxicology.  (Marcel Dekker, 270 Madison Ave., New
   York, NY 10016) V.1-    1977/78-  Volume(issue)/page/year: 18,271,1995

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
S

Warnings IRRITANT
WGK Germany1
Hazard Codes T T,Xi
Hazard statements
  • H227 Combustible liquid 可燃液体
  • H303 May be harmfully swallowed 吞食可能有害
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
    Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
    RTECSUY5790000
    Precautionary statements
    • P201 Obtain special instructions before use. 使用前获取专门指示。
    • P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前,切勿操作。
    • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
    • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
    • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
    • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
    • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
    • P302+P352
    • P302+P352+P332+P313+P362+P364
    • P304+P340+P312
    • P305+P351+P338
    • P305+P351+P338+P337+P313
    • P308+P313
    • P403+P233
    • P405 Store locked up. 上锁保管。
    • P501 Dispose of contents/container to..… 处理内容物/容器.....
      Signal word Danger
      Safety Statements
      • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
      • S53 Avoid exposure - obtain special instructions before use 避免接触,使用前获得特别指示说明;
        Risk Statements
        • R10 Flammable 易燃
        • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
        • R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性
        • R45 May cause cancer 可能致癌
        • R46 May cause inheritable genetic damage 可能引起遗传基因损害
        • R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害
        • R65 Harmful: may cause lung damage if swallowed 若吞咽可能伤害肺部器官
          Storage condition 易吸潮,密封避光保存。 Light Sensitive & Hygroscopic 充氩保存 2-8°C Hygroscopic
          UN Number UN 1268 3/PG 3
        • 用作溶剂及萃取剂。
        • NMP是一种极性的非质子传递溶剂,具有毒性小,沸点高,溶解能力出众,选择性强和稳定性好的优点。广泛用于芳烃萃取;乙炔、烯烃、二烯烃的纯化。也用于聚合物的溶剂及聚合反应的介质要。如聚酰胺、聚酰亚胺、聚苯硫醚等工程塑料及芳纶纤维。另外还用于绝缘材料、农药、颜料及清洁剂等方面。
        • {uni_hamburg} Short: III/35B
        • {ALD} Merck: 14,6117
        • {ALF} Nucleophilic displacement reactions with CN-: J. Chem. Soc., 954 (1962). Preparation of thiophenols from unactivated aryl chlorides and Na alkanethiolates: J. Org. Chem., 56, 3728 (1991). Reaction of thiophenol and potassium carbonate in uncatalyzed substitution reactions of chloroanilines and chloroanilides: J. Org. Chem., 56, 862 (1991). Synthesis of alkylaryl and alkylheteroaryl ethers, catalyzed by Cu(I): Tetrahedron, 48, 3633 (1992).
        • {ALF} Water-miscible, high-boiling dipolar aprotic solvent, compare N,N-Dimethyl­formamide, A13547 and Dimethyl­ sulfoxide, A13280, used in a wide variety of reactions, e.g.:
        • {uni_hamburg} Short: III/35D3
        • {ALD} Merck: 14,6117
        • Beilstein:21,237
        • 872-50-4 H86968 1-Methyl-2-pyrrolidone	1-甲基-2-吡咯烷酮

          化学属性

          Mol. FormulaC5H9NO
          Mol. Weight99.13
          Boiling Point202
          TSCAYes
          Melting Point-24
          Refractive index1.4680 to 1.4720
          Density1.028
          Autoignition Point518 °F
          Vapor Density3.4 (vs air)
          Vapor Pressure0.29 mmHg ( 20 °C)
          Flash Point95°C(lit.)
          Stability对水分敏感,充氩气保存
          Appearance 无色透明油状液体,微有胺的气味。 能与水、醇、醚、酯、酮、卤代烃、芳烃互溶。
          SolubilitySoluble in water (fully), chloroform, and methanol.