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4-Chloro-1,2-Diaminobenzene 4-氯-1,2-苯二胺

规格: 98%

CAS: 95-83-0

产品编号: H75616

MDL: MFCD00011691

品牌: INFI

Chemical Name	4-Chloro-1,2-Diaminobenzene
CAS Number	95-83-0
Alfabeta Name	CHLORODIAMINOBENZENE 412---,
MDL Number	MFCD00011691
Synonym	4-Chlorobenzene-1,2-diamine {LY} 4-Chlorobenzene-1,2-diamine {} {LY} 4-Chlorobenzene-1,2-diamine {} {} {LY} 4-Chlorobenzene-1,2-diamine {} {} {} {LY} 4-Chlorobenzene-1,2-diamine {} {} {} {} {LY} 4-Chlorobenzene-1,2-diamine {} {} {} {} {} {LY} 4-Chlorobenzene-1,2-diamine {} {} {} {} {} {} {LY} 4-Chlorobenzene-1,2-diamine {} {} {} {} {} {} {} {LY} 4-Chlorobenzene-1,2-diamine {} {} {} {} {} {} {} {} {LY} 4-Chlorobenzene-1,2-diamine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Chlorobenzene-1,2-diamine {} {} {} {} {} {} {} {} {} {} {LY} 4-Chlorobenzene-1,2-diamine {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Chlorobenzene-1,2-diamine {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Chlorobenzene-1,2-diamine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Chlorobenzene-1,2-diamine {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 4-Chlorobenzene-1,2-diamine {} {} {} {} {} {} {} {} {} {} {}
PubChem Substance ID	7263
EC Number	202-456-8
Beilstein Registry Number	508472
Reaxys-RN	508472
Chemical Name Translation	4-氯-1,2-苯二胺
Wiswesser Line Notation	ZR BZ DG
LabNetwork Molecule ID	LN00174243
InChI	InChI=1S/C6H7ClN2/c7-4-1-2-5(8)6(9)3-4/h1-3H,8-9H2
Canonical SMILES	C1=C(Cl)C=CC(=C1N)N

GHS Symbol

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 18750 gm/kg/2Y-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Liver - tumors
   Kidney, Ureter, Bladder - tumors
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 1,495,1980

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 136 gm/kg/78W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Gastrointestinal - tumors
   Kidney, Ureter, Bladder - tumors
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Volume(issue)/page/year: NCI-TR-63,1978

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 273 gm/kg/78W-C
TOXIC EFFECTS :
   Tumorigenic - Carcinogenic by RTECS criteria
   Gastrointestinal - tumors
   Kidney, Ureter, Bladder - tumors
REFERENCE :
   NCITR* National Cancer Institute Carcinogenesis Technical Report Series.
   (Bethesda, MD)  No.0-205. For publisher information, see NTPTR*.
   Vol

TYPE OF TEST            : TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 40500 gm/kg/96W-C
TOXIC EFFECTS :
   Tumorigenic - neoplastic by RTECS criteria
   Liver - tumors
REFERENCE :
   CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House,
   Southfield Road, Eynsham, Oxford OX8 1JJ, UK)  V.1-    1980-
   Volume(issue)/page/year: 1,495,1980

{hazard_

TYPE OF TEST            : Micronucleus test
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 259,43,1991

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 1 mg/plate
REFERENCE :
   ENMUDM Environmental Mutagenesis.  (New York, NY)  V.1-9, 1979-87.  For
   publisher information, see EMMUEG.  Volume(issue)/page/year: 7(Suppl

TYPE OF TEST            : Sister chromatid exchange
ROUTE OF EXPOSURE       : Intraperitoneal
TEST SYSTEM             : Rodent - mouse
DOSE/DURATION           : 400 mg/kg
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   14,207,1989

TYPE OF TEST            : Mutation test systems - not otherwise specified
TEST SYSTEM             : Bacteria - Escherichia coli
DOSE/DURATION           : 274 umol/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   19,98,1992

TYPE OF TEST            : DNA damage
TEST SYSTEM             : Human Fibroblast
DOSE/DURATION           : 50 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 127,107,1984

TYPE OF TEST            : Unscheduled DNA synthesis
TEST SYSTEM             : Rodent - rat Liver
DOSE/DURATION           : 1 umol/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(

Warnings	IRRITANT
WGK Germany	3
Hazard statements
H315 Causes skin irritation 会刺激皮肤 H351 Suspected of causing cancer 怀疑致癌 H319 Causes serious eye irritation 严重刺激眼睛 H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment	Eyeshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Hazard Codes	Xn
RTECS	SS8850000
Precautionary statements
P201 Obtain special instructions before use. 使用前获取专门指示。 P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。 P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。 P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。 P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。 P281 Use personal protective equipment as required. 使用所需的个人防护装备。 P302+P350 P304+P340 P305+P351+P338 P308+P313 P332+P313 P337+P313 P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用 P403+P233 P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word	Warning
Safety Statements
S20 When using do not eat or drink 使用时，不得进食，饮水； S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见； S36 Wear suitable protective clothing 穿戴适当的防护服； S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套； S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）； S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
Risk Statements
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性 R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
UN Number	2811
Storage condition	2-8°C, protect from light {LY} 2-8°C, protect from light {} {LY} 2-8°C, protect from light {} {} {LY} 2-8°C, protect from light {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

发生环化及环缩合反应，形成苯并咪唑

{SA}

Beil. 13 ,IV,68

{SA}

Aldrich MSDS 1 , 442:A / Corp MSDS 1 (1), 837:A / FT-IR 1 (1), 1237:B / FT-IR 2 (2), 2099:A / IR-Spectra (2), 651:E / IR-Spectra (3), 740:F / NMR-Reference 2 (1), 1046:D / RegBook 1 (1), 1429:G / Sigma FT-IR 1 (2), 390:D / Structure Index 1 , 223:A:4

95-83-0 H75616 4-Chloro-1,2-Diaminobenzene
4-氯-1,2-苯二胺

化学属性

Mol. Formula	C6H7ClN2
Mol. Weight	142.59
Melting Point	70-73°C
TSCA	Yes
Solubility	16 G/L (20 ºC)
Boiling Point	232.49 °C at 760 mmHg

*以上化合物性质及应用等信息仅供参考

手性催化剂及配体

合成砌块

医药中间体

4-Chloro-1,2-Diaminobenzene 4-氯-1,2-苯二胺

规格: 98%

化学属性

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