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1-Methyl-2-pyrrolidinone 1-甲基-2-吡咯烷酮

规格: 99%

CAS: 872-50-4

产品编号: H67435

MDL: MFCD00003193

品牌: INFI

Chemical Name	1-Methyl-2-pyrrolidinone
CAS Number	872-50-4
Alfabeta Name	METHYLPYRROLIDINONE 12---
MDL Number	MFCD00003193
Synonym	M-Pyrol N-ME N-Methyl-2-pyrrolidone N-Methylpyrolidon N-methylpyrrolidinone {} {} {} {} {} {} {Chemicalbook}
PubChem Substance ID	354334395
EC Number	212-828-1
Beilstein Registry Number	106420
Merck Number	6117
Reaxys-RN	106420
Chemical Name Translation	N-甲基吡咯烷酮
Wiswesser Line Notation	T5NVTJ A
LabNetwork Molecule ID	LN00164397
InChI	InChI=1S/C5H9NO/c1-6-4-2-3-5(6)7/h2-4H2,1H3

GHS Symbol

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 80500 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IYKEDH Iyakuhin Kenkyu.  Study of Medical Supplies.  (Nippon Koteisho
   Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan)  V.1- 1970- 
   Volume(issue)/page/year: 18,922,1987

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2472 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   ARZNAD Arzneimittel-Forschung. Drug Research.  (Editio Cantor Verlag,
   Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.)  V.1-    1951-
   Volume(issue)/page/year: 26,1581,1976

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 5130 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   EPASR* United States Environmental Protection Agency, Office of Pesticides
   and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW,
   Washington, DC 20460)  History unknown.  Volume(issue)/page/year:
   8EHQ-1087-0695

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Unreported
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 7 gm/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York,
   Academic Press, Inc., 1969  Volume(issue)/page/year: -,408,1969

TYPE OF TEST            : LD50 - Lethal dose,

TYPE OF TEST            : Sex chromosome loss and nondisjunction
TEST SYSTEM             : Yeast - Saccharomyces cerevisiae
DOSE/DURATION           : 154 mmol/L
REFERENCE :
   EMMUEG Environmental and Molecular Mutagenesis.  (Alan R. Liss, Inc., 41 E.
   11th St., New York, NY 10003)  V.10-    1987-  Volume(issue)/page/year:
   11,31,1988

TYPE OF TEST            : TCLo - Lowest published toxic concentration
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 150 ppm/6H
SEX/DURATION            : female 7-20 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Effects on Newborn - growth statistics (e.g.%, reduced weight
   gain)
   Reproductive - Effects on Newborn - delayed effects
REFERENCE :
   NETEEC Neurotoxicology and Teratology.  (Pergamon Press Inc., Maxwell House,
   Fairview Park, Elmsford, NY 10523)  V.9-    1987- Volume(issue)/page/year:
   16,241,1994

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 166 mg/kg
SEX/DURATION            : female 9 day(s) after conception
TOXIC EFFECTS :
   Reproductive - Fertility - post-implantation mortality (e.g. dead and/or
   resorbed implants per total number of implants)
   Reproductive - Specific Developmental Abnormalities - Central Nervous System
   Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
   BIRUAA Biologische Rundschau.  (VEB Gustav Fischer Verlag, Postfach 176,
   Jena DDR-6900, Ger. Dem. Rep.)  V.1-    1963-  Volume(issue)/page/year:
   14,38,1976

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Inhalation
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 116 ppm/6H
SEX/DURATION            : multigenerations
TOXIC EFFECTS :
   Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death,
   e.g., stunted fetus)
REFERENCE :
   DCTODJ Drug and Chemical Toxicology.  (Marcel Dekker, 270 Madison Ave., New
   York, NY 10016) V.1-    1977/78-  Volume(issue)/page/year: 18,271,1995

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Intraperitoneal
S

Warnings	IRRITANT
WGK Germany	1
Hazard Codes	T T,Xi
Hazard statements
H227 Combustible liquid 可燃液体 H303 May be harmfully swallowed 吞食可能有害 H315 Causes skin irritation 会刺激皮肤 H319 Causes serious eye irritation 严重刺激眼睛 H335 May cause respiratory irritation 可能导致呼吸道刺激 H360 May damage fertility or the unborn child 可能对生育能力或未出生婴儿造成伤害
Personal Protective Equipment	Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter Eyeshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
RTECS	UY5790000
Precautionary statements
P201 Obtain special instructions before use. 使用前获取专门指示。 P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。 P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。 P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。 P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。 P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。 P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。 P302+P352 P302+P352+P332+P313+P362+P364 P304+P340+P312 P305+P351+P338 P305+P351+P338+P337+P313 P308+P313 P403+P233 P405 Store locked up. 上锁保管。 P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word	Danger
Safety Statements
S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）； S53 Avoid exposure - obtain special instructions before use 避免接触，使用前获得特别指示说明；
Risk Statements
R10 Flammable 易燃 R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性 R36/38 Irritating to eyes and skin 对眼睛和皮肤有刺激性 R45 May cause cancer 可能致癌 R46 May cause inheritable genetic damage 可能引起遗传基因损害 R61 May cause harm to the unborn child 可能对未出生的婴儿导致伤害 R65 Harmful: may cause lung damage if swallowed 若吞咽可能伤害肺部器官
Storage condition	易吸潮,密封避光保存。 Light Sensitive & Hygroscopic 充氩保存 2-8°C Hygroscopic
UN Number	UN 1268 3/PG 3

用作溶剂及萃取剂。

NMP是一种极性的非质子传递溶剂，具有毒性小，沸点高，溶解能力出众，选择性强和稳定性好的优点。广泛用于芳烃萃取；乙炔、烯烃、二烯烃的纯化。也用于聚合物的溶剂及聚合反应的介质要。如聚酰胺、聚酰亚胺、聚苯硫醚等工程塑料及芳纶纤维。另外还用于绝缘材料、农药、颜料及清洁剂等方面。

{uni_hamburg} Short: III/35B

{ALD} Merck: 14,6117

{ALF} Nucleophilic displacement reactions with CN-: J. Chem. Soc., 954 (1962). Preparation of thiophenols from unactivated aryl chlorides and Na alkanethiolates: J. Org. Chem., 56, 3728 (1991). Reaction of thiophenol and potassium carbonate in uncatalyzed substitution reactions of chloroanilines and chloroanilides: J. Org. Chem., 56, 862 (1991). Synthesis of alkylaryl and alkylheteroaryl ethers, catalyzed by Cu(I): Tetrahedron, 48, 3633 (1992).

{ALF} Water-miscible, high-boiling dipolar aprotic solvent, compare N,N-Dimethylformamide, A13547 and Dimethyl sulfoxide, A13280, used in a wide variety of reactions, e.g.:

{uni_hamburg} Short: III/35D3

{ALD} Merck: 14,6117

Beilstein:21,237

872-50-4 H67435 1-Methyl-2-pyrrolidinone
1-甲基-2-吡咯烷酮

化学属性

Mol. Formula	C5H9NO
Mol. Weight	99
Boiling Point	202
TSCA	Yes
Melting Point	-24
Refractive index	1.4680 to 1.4720
Density	1.028
Autoignition Point	518 °F
Vapor Density	3.4 (vs air)
Vapor Pressure	0.29 mmHg ( 20 °C)
Flash Point	95°C(lit.)
Stability	对水分敏感，充氩气保存
Appearance	无色透明油状液体，微有胺的气味。能与水、醇、醚、酯、酮、卤代烃、芳烃互溶。
Solubility	Soluble in water (fully), chloroform, and methanol.

手性催化剂及配体

合成砌块

医药中间体

1-Methyl-2-pyrrolidinone 1-甲基-2-吡咯烷酮

规格: 99%

化学属性

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