Chemilly-天津启瑞生物科技有限公司

Baicalein 黄芩素

规格: 98%

CAS: 491-67-8

产品编号: H64921

MDL: MFCD00017459

品牌: INFI

Chemical Name	Baicalein
Synonym	Baicalein {LY} Baicalein {} {LY} Baicalein {} {} {LY} Baicalein {} {} {} {LY} Baicalein {} {} {} {} {LY} Baicalein {} {} {} {} {} {LY} Baicalein {} {} {} {} {} {} {LY} Baicalein {} {} {} {} {} {} {} {LY} Baicalein {} {} {} {} {} {} {} {} {LY} Baicalein {} {} {} {} {} {} {} {} {} {LY} Baicalein {} {} {} {} {} {} {} {} {} {} {LY} Baicalein {} {} {} {} {} {} {} {} {} {} {} {LY} Baicalein {} {} {} {} {} {} {} {} {} {} {} {} {LY} Baicalein {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Baicalein {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Baicalein {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Baicalein {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Baicalein {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Baicalein {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Baicalein {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
MDL Number	MFCD00017459
PubChem Substance ID	5281605
Beilstein Registry Number	272683
CAS Number	491-67-8
Reaxys-RN	272683
Merck Number	942
Chemical Name Translation	黄芩素
InChI	InChI=1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H
LabNetwork Molecule ID	LN00194973
Canonical SMILES	O=C1C=C(C2=CC=CC=C2)OC3=CC(O)=C(O)C(O)=C13

GHS Symbol

WGK Germany	3
Precautionary statements
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。 P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用 P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。 P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。 P305+P351+P338
Hazard statements
H315 Causes skin irritation 会刺激皮肤 H319 Causes serious eye irritation 严重刺激眼睛 H335 May cause respiratory irritation 可能导致呼吸道刺激
Hazard Codes	Xi
Personal Protective Equipment	dust mask type N95 (US), Eyeshields, Gloves
Signal word
RTECS	DJ3100898
Storage condition	2-8°C, protect from light {LY} 2-8°C, protect from light {} {LY} 2-8°C, protect from light {} {} {LY} 2-8°C, protect from light {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
Safety Statements
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见； S37 Wear suitable gloves 戴适当手套； S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性

An inhibitor of Ca2+ uptake, 5-LO, and 12-LO

{MCE} [2]. Patwardhan RS, et al. Baicalein exhibits anti-inflammatory effects via inhibition of NF-κB transactivation. Biochem Pharmacol. 2016 May 15;108:75-89.

{MCE} [3]. Ma X, et al. Baicalein suppresses metastasis of breast cancer cells by inhibiting EMT via downregulation of SATB1 and Wnt/β-catenin pathway.

{MCE} [4]. Kong EK, et al. A novel anti-fibrotic agent, baicalein, for the treatment of myocardial fibrosis in spontaneously hypertensiverats. Eur J Pharmacol. 2011 May 11;658(2-3):175-81.

{MCE} Drug Des Devel Ther. 2016 Apr 18;10:1419-41.

{SA} Merck 14 ,942

{ALD} Merck: 14,942

Beilstein:18(5)4,569

{MCE} [1]. Shieh DE,et al. Antioxidant and free radical scavenging effects of baicalein, baicalin and wogonin. Anticancer Res. 2000 Sep-Oct

{MCE} [1]. Shieh DE,et al. Antioxidant and free radical scavenging effects of baicalein, baicalin and wogonin. Anticancer Res. 2000 Sep-Oct;20(5A):2861-5.

化学属性

Mol. Formula	C15H10O5
Mol. Weight	270.24
Melting Point	256-271°C
TSCA	No
Density	1.548
Appearance	黄色粉末，熔点264-265℃，溶于乙醇、甲醇、乙醚、丙酮、醋酸乙酯和热冰醋酸，微溶于氯仿和硝基苯，几乎不溶于水。溶于稀氢氧化钠呈绿棕色，溶于浓硫酸呈黄色并有绿色荧光。
Solubility	Soluble in alcohol, methanol, ether, acetone, ethyl acetate, hot glacial acetic acid, dilute sodium hydroxide, and DMSO (50 mM). Insoluble in water
Stability	对光和热敏感
Boiling Point	650.2°C at 760 mmHg

*以上化合物性质及应用等信息仅供参考

手性催化剂及配体

合成砌块

医药中间体

Baicalein 黄芩素

规格: 98%

化学属性

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