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2,2,2-Trifluoroacetophenone 2,2,2-三氟苯乙酮

规格: 99%

CAS: 434-45-7

产品编号: H58001

MDL: MFCD00000420

品牌: INFI

Chemical Name	2,2,2-Trifluoro-1-Phenylethanone
CAS Number	434-45-7
Alfabeta Name	TRIFLUOROACETOPHENONE 222-,,
MDL Number	MFCD00000420
Synonym	2,2,2-Trifluoro-1-phenylethan-1-one {LY} 2,2,2-Trifluoro-1-phenylethan-1-one {} {LY} 2,2,2-Trifluoro-1-phenylethan-1-one {} {} {LY} 2,2,2-Trifluoro-1-phenylethan-1-one {} {} {} {LY} 2,2,2-Trifluoro-1-phenylethan-1-one {} {} {} {} {LY} 2,2,2-Trifluoro-1-phenylethan-1-one {} {} {} {} {} {LY} 2,2,2-Trifluoro-1-phenylethan-1-one {} {} {} {} {} {} {LY} 2,2,2-Trifluoro-1-phenylethan-1-one {} {} {} {} {} {} {} {LY} 2,2,2-Trifluoro-1-phenylethan-1-one {} {} {} {} {} {} {} {} {LY} 2,2,2-Trifluoro-1-phenylethan-1-one {} {} {} {} {} {} {} {} {} {LY} 2,2,2-Trifluoro-1-phenylethan-1-one {} {} {} {} {} {} {} {} {} {} {LY} 2,2,2-Trifluoro-1-phenylethan-1-one {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {LY} 2,2,2-Trifluoro-1-phenylethan-1-one {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2,2,2-Trifluoro-1-phenylethan-1-one {} {} {} {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2,2,2-Trifluoro-1
EC Number	207-103-1
Beilstein Registry Number	7(3)962
PubChem Substance ID	9905
Reaxys-RN	1866286
Chemical Name Translation	2,2,2-三氟苯乙酮
LabNetwork Molecule ID	LN00008033
InChI	InChI=1S/C8H5F3O/c9-8(10,11)7(12)6-4-2-1-3-5-6/h1-5H
Canonical SMILES	FC(F)(F)C(C1=CC=CC=C1)=O

GHS Symbol

Warnings	LACHRYMATOR, FLAMMABLE
Signal word
WGK Germany	3
Safety Statements
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见； S37 Wear suitable gloves 戴适当手套； S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护； S36 Wear suitable protective clothing 穿戴适当的防护服； S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟；
Risk Statements
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性 R10 Flammable 易燃
Precautionary statements
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。 P233 Keep container tightly closed. ?保持容器密闭。 P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。 P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。 P241+P242+P243 P242 Use only non-sparking tools. 只能使用无火花工具。 P243 Take precautionary measures against static discharge. 采取预防措施，防止静电放电。 P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。 P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。 P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。 P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。 P302+P352 P302+P352+P332+P313+P362+P364 P303+P361+P353 P304+P340 P305+P351+P338 P305+P351+P338+P337+P313 P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。 P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。 P332+P313 P337+P313 P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用 P370+P378 P403+P233 P403+P235 P405 Store locked up. 上锁保管。 P501 Dispose of contents/container to..… 处理内容物/容器.....
Packing Group	III
UN Number	1224
Hazard statements
H226 Flammable liquid and vapour 易燃液体和蒸气 H315 Causes skin irritation 会刺激皮肤 H319 Causes serious eye irritation 严重刺激眼睛 H335 May cause respiratory irritation 可能导致呼吸道刺激
Personal Protective Equipment	Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Hazard Codes
Hazard Class	3
Storage condition	Store at room temperature {LY} Store at room temperature {} {LY} Store at room temperature {} {} {LY} Store at room temperature {} {} {} {LY} Store at room temperature {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Store at room temperature {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}

2,2,2-Trifluoroacetophenone is a fluorinated acetophenone with inhibitory activity of acetylcholinesterase. 2,2,2-Trifluoroacetophenone was shown to have neuroprotective activity by inhibiting apoptos

{ALF} Reaction with Dimethyl acetylenedicarboxylate, A11437, in the presence of triphenylphosphine, gives a highly-functionalized -butyrolactone: J. Org. Chem., 61, 4516 (1996):

{uni_hamburg} Short: III/35E

{ALF} In the presence of KO-t-Bu, acts as a nucleophilic trifluoromethylating agent, converting carbonyl compounds to trifluoromethyl alcohols: Tetrahedron Lett., 44, 1055 (2003).

{

{ALF} Trifluoromethyl ketones undergo selective C-F bond cleavage with Mg in the presence of TMSCl, providing a convenient synthesis of 2,2-difluoro enol silanes: Chem. Commun., 1323 (1999).

{uni_hamburg} Short: III/38B

{ALD} Beilstein:7(3)962

{TRC} Brodbeck, U. et al.: Biochim. Biphys. Acta Enzymol., 567, 357 (1979); Kawase, M. et al.: Biol. Pharmac. Bull., 24, 1335 (2001);

{ALF} In the presence of potassium monopersulfate (Oxone ), catalyzes the epoxidation of allylic alcohols via the in situ formed dioxirane: Tetrahedron, 56, 989 (1999).

{ALF} Olefination with methanesulfonyl chloride, promoted by KF in DMF, gives ɑ -(trifluoromethyl)styrene in 92% yield: J. Org. Chem., 59, 2898 (1994).

434-45-7 H58001 2,2,2-Trifluoroacetophenone
2,2,2-三氟苯乙酮

化学属性

Mol. Formula	C8H5F3O
Mol. Weight	174.12
Boiling Point	165-166 °C at 760 mmHg
TSCA	T
Density	1.24
Refractive index	1.4570 to 1.4620
Flash Point	41°C(lit.)
Melting Point	-40°C
Solubility	难溶

*以上化合物性质及应用等信息仅供参考

手性催化剂及配体

合成砌块

医药中间体

2,2,2-Trifluoroacetophenone 2,2,2-三氟苯乙酮

规格: 99%

化学属性

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