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Ninhydrin 茚三酮

规格: 95%

CAS: 485-47-2

产品编号: H52217

MDL: MFCD00003791

品牌: INFI

Chemical Name	Ninhydrin hydrate
Synonym	Ninhydrin {LY} Ninhydrin {} {LY} Ninhydrin {} {} {LY} Ninhydrin {} {} {} {LY} Ninhydrin {} {} {} {} {LY} Ninhydrin {} {} {} {} {} {LY} Ninhydrin {} {} {} {} {} {} {} {} {} {} {} {} {LY} Ninhydrin {} {} {} {} {} {} {} {LY} Ninhydrin {} {} {} {} {} {} {} {} {LY} Ninhydrin {} {} {} {} {} {} {} {} {} {LY} Ninhydrin {} {} {} {} {} {} {} {} {} {} { {} {} {} {} {} {} {} {} {} {} {LY} Ninhydrin {} {} {} {} {} {} {} {} {} {} {} {LY} Ninhydrin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Ninhydrin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Ninhydrin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Ninhydrin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Ninhydrin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} Ninhydrin {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {}
MDL Number	MFCD00003791
PubChem Substance ID	10236
Beilstein Registry Number	7(4)2786
CAS Number	485-47-2
EC Number	207-618-1
Reaxys-RN	1910963
Merck Number	6554
Chemical Name Translation	水合茚三酮
Wiswesser Line Notation	L56 BV DV CHJ CQ CQ
LabNetwork Molecule ID	LN00008752
InChI	InChI=1S/C9H6O4/c10-7-5-3-1-2-4-6(5)8(11)9(7,12)13/h1-4,12-13H
Canonical SMILES	O=C1C(O)(O)C(C2=C1C=CC=C2)=O

GHS Symbol

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 78 mg/kg
TOXIC EFFECTS :
   Behavioral - somnolence (general depressed activity)
   Vascular - regional or general arteriolar or venous dilation
   Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
   CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses
   Filiales.  (SPPIF, B.P.22, F-41353 Vineuil, France)  V.1-    1849-
   Volume(issue)/page/year: 151,719,1957

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 250 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   NCNSA6 National Academy of Sciences, National Research Council,
   Chemical-Biological Coordination Center, Review.  (Washington, DC)
   Volume(issue)/page/year: 5,28,1953

WGK Germany	1
Precautionary statements
P201 Obtain special instructions before use. 使用前获取专门指示。 P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。 P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。 P233 Keep container tightly closed. ?保持容器密闭。 P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。 P241+P242+P243 P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。 P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。 P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。 P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。 P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。 P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。 P284 Wear respiratory protection.? 佩戴呼吸保护装置。 P301+P312+P330 P302+P352+P332+P313+P362+P364 P304+P340+P312 P305+P351+P338 P305+P351+P338+P337+P313 P308+P313 P350+P351+P338 P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用 P403+P233 P405 Store locked up. 上锁保管。 P501 Dispose of contents/container to..… 处理内容物/容器.....
Hazard statements
H223 Flammable aerosol 易燃气雾剂 H225 Highly flammable liquid and vapour 高度易燃液体和蒸气 H302 Harmful if swallowed 吞食有害 H315 Causes skin irritation 会刺激皮肤 H319 Causes serious eye irritation 严重刺激眼睛 H335 May cause respiratory irritation 可能导致呼吸道刺激
Hazard Codes	3
RTECS	Nk5425000
Personal Protective Equipment	dust mask type N95 (US), Eyeshields, Gloves
Signal word	Danger
Safety Statements
S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟； S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见； S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护； S7 Keep container tightly closed 保存在严格密闭容器中；
Risk Statements
R11 Highly flammable 非常易燃 R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害 R22 Harmful if swallowed 吞咽有害 R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性 R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed 毒性：吸入，皮肤接触和吞食都会产生十分严重的不可逆危险
UN Number	1170 1950 UN 1170 3/PG 2
Storage condition	2-8°C, protect from light {LY} 2-8°C, protect from light Light Sensitive Store at RT. {} {LY} 2-8°C, protect from light {} {} {LY} 2-8°C, protect from light {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, protect from light {} {} {} {} {} {} {} {}
Packing Group	II
Hazard Class	3

该品是蛋白质、氨基酸及蛋白胨的灵敏显色试剂。

〔水合〕茚三酮 ninhydrin 为茚三酮的水合物。是灵敏的氨基酸显色试剂。α-氨基酸与水合茚三酮一起加热显蓝紫色（脯氨酸和羟脯氨酸显黄色），称此为水合茚三酮反应。此反应应用于纸层析及滤纸电泳的氨基酸和肽的测定，以及氨基酸自动定量分析等。

{ALD} Merck: 14,6554

{ALF} Reviews: Chem. Rev., 60, 39 (1960); Tetrahedron, 34, 1285 (1978); 47, 8791 (1991).

{uni_hamburg} Short: EINECS

{ALF} Reagent for the detection and determination of peptides and amino acids.

{uni_hamburg} Short: III/10a

{SA} Kaiser, E., Kaiser test. Anal. Biochem. 34 , 595, (1970)

化学属性

Mol. Formula	C9H6O4
Mol. Weight	178.14
Melting Point	250°C
Density	0.862
TSCA	Yes
Solubility	Soluble in water and alcohol
Flash Point	13 °C
Appearance	淡黄色结晶性粉末，带1分子结晶水，熔点241-243℃（在125-130℃失水并变红）。溶于醇、水，微溶于醚和氯仿。见光或露置空气中逐渐变色，能吸潮结块。用途：该品是蛋白质、氨基酸及蛋白胨的灵敏试剂。该品高毒，小鼠腹腔注射LD50为78mg/kg。制备方法：将苯二甲酸二乙酯与乙酸乙酯在金属钠存在下反应，生成苯并戊二酮甲酸乙酯，经酸化失羧生成苯并戊二酮，再氧化生成水合茚三酮。 #EndEditable "Content"
Stability	对光线敏感
Boiling Point	449.3°C at 760 mmHg
Danger-Level	甲类

*以上化合物性质及应用等信息仅供参考

手性催化剂及配体

合成砌块

医药中间体

Ninhydrin 茚三酮

规格: 95%

化学属性

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