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Apigenin 芹菜素

规格: 98%

CAS: 520-36-5

产品编号: H45081

MDL: MFCD00006831

品牌: INFI

Chemical Name	Apigenin
CAS Number	520-36-5
Synonym	芹菜苷元 APIGENIN CRYSTALLINE 4,5,7-TRIHYDROXYFLAVONE 4',5,7-Trihydroxyflavone 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone 4',5,7-TRIHYDROXYFLAVONE APIGENIN FROM PARSLEY 4',5,7-Trihydroxyflavone Matricaria chamomilla flower 芹菜苷配基 agigenin 5,7,4'-三羟基黄酮 apigenol 4,5,7-Trihydroxyflavone (apigenin) 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one Chamomile 5,7,4'-TRIHYDROXYFLAVONE 4H-1-Benzopyran-4-one, 5,7-dihydroxy-2-(4-hydroxyphenyl)- 2-(p-hydroxyphenyl)-5,7-dihydroxychromone 芹黄素,4',5,7-三羟基黄酮,5,7,4'-三羟基黄酮 4,5,7-Trihydroxyflavone 5,7-dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone
MDL Number	MFCD00006831
Beilstein Registry Number	262620
EC Number	208-292-3
Reaxys-RN	262620
PubChem Substance ID	5280443
Merck Number	730
Chemical Name Translation	芹菜素
Wiswesser Line Notation	T66 BO EVJ CR DQ& GQ IQ
LabNetwork Molecule ID	LN00215854
InChI	InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H

GHS Symbol

TYPE OF TEST            : Mutation in microorganisms
TEST SYSTEM             : Bacteria - Salmonella typhimurium
DOSE/DURATION           : 100 ug/plate
REFERENCE :
   BCSTB5 Biochemical Society Transactions.  (Biochemical Soc. Book Depot, POB
   32, Commerce Way, Colchester, Essex CO2 8HP, UK)  V.1-    1973-
   Volume(issue)/page/year: 5,1489,1977

TYPE OF TEST            : Micronucleus test
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 5 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 246,205,1991

TYPE OF TEST            : Sister chromatid exchange
TEST SYSTEM             : Human Lymphocyte
DOSE/DURATION           : 10 mg/L
REFERENCE :
   MUREAV Mutation Research.  (Elsevier Science Pub. B.V., POB 211, 1000 AE
   Amsterdam, Netherlands) V.1-    1964-  Volume(issue)/page/year: 246,205,1991

RTECS	LK9276000
Precautionary statements
P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。 P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用 P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。 P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。 P305+P351+P338 P332+P313 P305+P351+P338+P337+P313 P302+P350 P337+P313
Hazard statements
H315 Causes skin irritation 会刺激皮肤 H319 Causes serious eye irritation 严重刺激眼睛 H335 May cause respiratory irritation 可能导致呼吸道刺激
WGK Germany	3
Signal word
Safety Statements
S36 Wear suitable protective clothing 穿戴适当的防护服； S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见； S37 Wear suitable gloves 戴适当手套； S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
Risk Statements
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Personal Protective Equipment	dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes	Xi
Storage condition	-20°C 避光,储存温度-20°C

黄酮类化合物(flavonoid),能捕获细胞周期的G2/M期，抑制细胞扩增。抑制生长，诱发凋亡，用于肿瘤药物。

{MCE} [2]. Wu K, et al. Inhibitory effects of apigenin on the growth of gastric carcinoma SGC-7901 cells. World J Gastroenterol. 2005 Aug 7;11(29):4461-4.

{MCE} [3]. Yu W, et al. Apigenin Attenuates Adriamycin-Induced Cardiomyocyte Apoptosis via the PI3K/AKT/mTOR Pathway. Evid Based Complement Alternat Med. 2017;2017:2590676.

{TRC} Chaumontet, C., et al.: Carcinogenesis, 15, 2325 (1994),

{SA} Czyz, J., et al., Hierarchy of carcinoma cell responses to apigenin: gap junctional coupling versus proliferation. Oncol. Rep. 11 , 739-744, (2004)

{SA} Huang, Y.T., et al., Inhibition of protein kinase C and proto-oncogene expression in NIH 3T3 cells by apigenin. Eur. J. Cancer 32A , 146-151, (1996) 摘要

{ALD} Merck: 14,730

Beilstein:18(5)4,574

{SA} Plaumann, B., et al., Flavonoids activate wild-type p53. Oncogene 13 , 1605-1614, (1996) 摘要

{SA} Sato, F., et al., Apigenin induces morphological differentiation and G2-M arrest in rat neuronal cells. Biochem

化学属性

Mol. Formula	C15H10O5
Mol. Weight	270
Melting Point	>300
TSCA	No
Density	1.548
Stability	对光敏感
Appearance	黄色针状结晶（吡啶水溶液），熔点345-350℃。几乎不溶于水，尚易溶于热乙醇。UVλEtOH max nm(ε):269(18800); 300(13500), 340(20900)。 powder
Solubility	DMSO: 27 mg/mL

*以上化合物性质及应用等信息仅供参考

手性催化剂及配体

合成砌块

医药中间体

Apigenin 芹菜素

规格: 98%

化学属性

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