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Propargyl bromide 炔丙基溴

规格: 80 wt.% solution in toluene, stabilized with 0.3% magnesium oxide, SpcSeal
CAS: 106-96-7
产品编号: H41894
MDL: MFCD00000241
品牌: INFI
Chemical NamePropargyl bromide
Synonym propyn-2-yl bromide Propargyl bromide PROPARGYL BROMIDE 2-Propynyl bromide PROPARGYL BROMIDE, 80 WT. % SOLUTION IN TOLUENE G-BROMOALLYLENE PROPARGYL BROMIDE SOLUTION, ~80% IN TOLU ENE, STAB. 3-Bromopropyne 3-溴丙炔;溴丙炔;炔丙基溴;3-溴-1-丙炔 1-Propyne, 3-bromo- 3-Brom-1-propin 溴丙炔 Propargylbromid gamma-Bromoallylene 3-bromo-1-propyn propargylbromide101 3-Bromo-1-propyne -Bromo-propyne 炔丙基溴 溶液 3-bromo-propyn 炔丙基溴/3-溴丙炔 1-Bromo-2-propyne 3-Brompropin 3-溴丙炔
CAS Number106-96-7
Beilstein Registry Number1,248
MDL NumberMFCD00000241
PubChem Substance ID87574670
EC Number203-447-1
Reaxys-RN605309
Chemical Name Translation炔丙基溴
Wiswesser Line NotationE2UU1
LabNetwork Molecule IDLN00196370
InChIInChI=1S/C3H3Br/c1-2-3-4/h1H,3H2
GHS Symbol
TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - guinea pig
DOSE/DURATION           : 29 ug/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College
   Science Pub., 1969  Volume(issue)/page/year: 4,76,1969

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 53 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   BESAAT Bulletin of the Entomological Society of America.  (Entomological
   Soc. of America, 4603 Calvert Rd., College Park, MD 20740)  V.1-    1955-
   Volume(issue)/page/year: 12,161,1966

WGK Germany3
Hazard statements
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H301 Toxic if swallowed 吞食有毒
  • H304 May be fatal if swallowed and enters airways 吞食和进入呼吸道可能致命
  • H315 Causes skin irritation 会刺激皮肤
  • H319 Causes serious eye irritation 严重刺激眼睛
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H336 May cause drowsiness or dizziness 肯能导致嗜睡或头晕
  • H361d Suspected of damaging the unborn child 怀疑对未出生婴儿造成伤害
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
    Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
    Hazard Codes F,T F;T
    Precautionary statements
    • P201 Obtain special instructions before use. 使用前获取专门指示。
    • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
    • P233 Keep container tightly closed. ?保持容器密闭。
    • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
    • P241+P242+P243
    • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
    • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
    • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
    • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
    • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
    • P301+P310
    • P301+P310+P330
    • P302+P352+P332+P313+P362+P364
    • P303+P361+P353
    • P304+
    • P305+P351+P338
    • P305+P351+P338+P337+P313
    • P314 Get medical advice/attention if you feel unwell. 获取医疗咨询/就医,如果你觉得不舒服
    • P332+P313
    • P337+P313
    • P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服,清洗后方可重新使用
    • P403+P233
    • P403+P235
    • P405 Store locked up. 上锁保管。
    • P501 Dispose of contents/container to..… 处理内容物/容器.....
      Signal word
      Safety Statements
      • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
      • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
      • S36/37 Wear suitable protective clothing and gloves 穿戴适当的防护服和手套;
      • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
      • S62 If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label where possible 吞食后不要催吐:立即求医并出示该容器或标签;
      • S37/39 Wear suitable gloves and eye/face protection 穿戴适当的手套和眼睛/面保护;
      • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后,立即用大量…(由生产厂家指定)冲洗;
      • S20 When using do not eat or drink 使用时,不得进食,饮水;
      • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾;
      • S33 Take precautionary measures against static discharges 对静电采取预防措施;
      • S60 This material and its container must be disposed of as hazardous waste 该物质及其容器必须作为危险废物处置;
      • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
      • S9 Keep container in a well-ventilated place 保持容器在通风良好的场所;
        Risk Statements
        • R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
        • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
        • R25 Toxic if swallowed 吞咽有毒
        • R11 Highly flammable 非常易燃
        • R48/20
        • R65 Harmful: may cause lung damage if swallowed 若吞咽可能伤害肺部器官
        • R67 Vapours may cause drowsiness and dizziness 蒸汽可能导致嗜睡和昏厥
        • R37 Irritating to respiratory system 刺激呼吸道
        • R34 Causes burns 会导致灼伤
          UN Number 1993 2345
          RTECSUK4375000
          Storage condition 0-10 0-10°C Light Sensitive Refrigerator 储存温度2-8℃,充氩保存 密封2-8°C保存。
          Packing GroupII
          Hazard Class3
          Warnings 危化品目录(2015)
        • 用于合成乙炔各种衍生物;医药工业用于制造抗霉菌药氯丙炔碘。用于制造丙炔胺(烯炔替代)。
        • {uni_hamburg} Short: II/19b
        • {ALD} Beilstein: 1,IV,964
        • {ALF} Barbier-type reaction with aldehydes in aqueous THF gives the secondary alcohols in moderate to good yields: Synth. Commun., 25, 2923 (1995); partial rearrangement to the allene could occur; cf Allyl­ bromide, A11766, for similar reactions. For reaction with aldehydes in the presence of Zn in THF, and transformation of the resulting secondary alcohols into pyruvate esters, see: J. Chem. Chem. Commun ., 1289 (1991).
        • {ALF} With Mg in ether, generates allenylmagnesium bromide which can be coupled with a further molecule of propargyl bromide to give the bis-allene 1,2,4,5-hexatetraene: Org. Synth. Coll., 7, 485 (1990). Diels-Alder reaction of the product with Dimethyl­ acetyl­enedicarboxyl­ate, A11437 leads to a para-cyclophane.
        • {ALF} For diastereoselective propargylation of ɑ -alkoxy aldehydes and application in the synthesis of oxygenated acyclic natural products, see: J. Org. Chem., 60, 3257 (1995).
        • {ALF} For conversion to dimethyl-2-propynylsulfonium bromide and condensation with 2,4-pentanedione and other active methylene compounds in a versatile, high-yield synthesis of substituted furans, see: J. Chem. Soc., Perkin 1, 65 (1973); Org. Synth. Coll ., 6, 31 (1988).
        • 106-96-7 H41894 Propargyl bromide
炔丙基溴

          化学属性

          Mol. FormulaC3H3Br
          Mol. Weight118.96
          Density1.335
          Refractive index1.4910 to 1.4970
          Boiling Point90°C
          Flash Point10°C(lit.)
          TSCAYes
          Melting Point-61°
          Solubility溶于苯、乙醚、乙醇和氯仿。不易和水混溶。
          Stability对空气,光和热敏感