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tert-Butylchlorodimethylsilane 叔丁基二甲基氯硅烷

规格: 1.0 M solution in THF, SpcSeal
CAS: 18162-48-6
产品编号: H28742
MDL: MFCD00000501
品牌: INFI
Chemical Nametert-Butyldimethylchlorosilane
CAS Number18162-48-6
Synonym chloro(1,1-dimethylethyl)dimethyl-silan SILANE, CHLORO(1,1-DIMETHYLETHYL)DIMETHYL- TBDMSCl Chloro-tert-butyldimethyl-silane ( TBDMSCl 溶液 叔丁基二甲基氯硅烷 叔丁基二甲基硅基氯 叔丁基氯二甲基硅烷 溶液 {Chemical BDCS SILYLATION REAGENT tert-Butyl dimethylchloro silane tert-Butylchlorodimethy tert-Butylchlorodimethylsilanetert-Butyldimethylsilyl chloride Chlorodimethyl-tert-butylsilane (1,1-Dimethylethyl)d TBDMSCl 溶液 叔丁基二甲基氯硅烷 叔丁基二甲基硅基氯 chloro TERT-BUTYLDIMETHYLSILYL CHLORIDE tert-Butylchlorodimethylsilane {Chem 叔丁基二甲基硅基氯 溶液 BDCS TBDMSCI 叔丁基氯二甲基硅烷 TBDMS chloride tert-Bu
PubChem Substance ID24870907
EC Number242-042-4
Beilstein Registry Number505999
MDL NumberMFCD00000501
Chemical Name Translation叔丁基二甲基氯硅烷
Wiswesser Line NotationG-SI-1&1&X1&1&1
LabNetwork Molecule IDLN00163233
GHS Symbol
TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Intraperitoneal
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 1 gm/kg
   Immunological Including Allergic - decreased immune response
   StoGD# Personal Communication from G.D. Stoner, Dept. of Community Medicine,
   School of Medicine, Univ. of California, La Jolla, CA 92037, May 25, 1975 
   Volume(issue)/page/year: 27MAY1975

WGK Germany2
Hazard statements
  • H314 Causes severe skin burns and eye damage 导致严重的皮肤灼伤和眼睛损伤
  • H351 Suspected of causing cancer 怀疑致癌
  • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
  • H335 May cause respiratory irritation 可能导致呼吸道刺激
  • H228 Flammable solid 易燃固体
  • H302 Harmful if swallowed 吞食有害
  • H226 Flammable liquid and vapour 易燃液体和蒸气
  • H304 May be fatal if swallowed and enters airways 吞食和进入呼吸道可能致命
  • H336 May cause drowsiness or dizziness 肯能导致嗜睡或头晕
  • H361d Suspected of damaging the unborn child 怀疑对未出生婴儿造成伤害
  • H373 May causes damage to organs through prolonged or repeated exposure 长期或频繁接触可能会损伤器官
    Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter Faceshields, full-face respirator (US), Gloves, Goggles, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
    Precautionary statements
    • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
    • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
    • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
    • P305+P351+P338
    • P501 Dispose of contents/container to..… 处理内容物/容器.....
    • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
    • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
    • P370+P378
    • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
    • P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。
    • P305+P351+P338+P310
      Signal word
      Safety Statements
      • S53 Avoid exposure - obtain special instructions before use 避免接触,使用前获得特别指示说明;
      • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
      • S33 Take precautionary measures against static discharges 对静电采取预防措施;
      • S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时,立即求医(可能时出示标签);
      • S46 If swallowed, seek medical advice immediately and show this container or label 食入时,立即求医并出示容器/标签;
      • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
      • S27 Take off immediately all contaminated clothing 立即脱掉全部污染的衣服;
      • S25 Avoid contact with eyes 避免眼睛接触;
      • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
      • S28 After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) 皮肤接触后,立即用大量…(由生产厂家指定)冲洗;
      • S29 Do not empty into drains 不要排入下水道;
      • S62 If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label where possible 吞食后不要催吐:立即求医并出示该容器或标签;
        Packing GroupII
        UN Number UN2924
        Risk Statements
        • R11 Highly flammable 非常易燃
        • R67 Vapours may cause drowsiness and dizziness 蒸汽可能导致嗜睡和昏厥
        • R63 Possible risk of harm to the unborn child 可能危害未出生婴儿
        • R48/20
        • R34 Causes burns 会导致灼伤
        • R19 May form explosive peroxides 可能生成易爆的过氧化物质
        • R37 Irritating to respiratory system 刺激呼吸道
        • R40 Limited evidence of a carcinogenic effect 有限证据表明其致癌作用
        • R45 May cause cancer 可能致癌
        • R10 Flammable 易燃
        • R20/21/22 Harmful by inhalation, in contact with skin and if swallowed 吸入、皮肤接触和不慎吞咽有害
        • R65 Harmful: may cause lung damage if swallowed 若吞咽可能伤害肺部器官
        • R35 Causes severe burns 会导致严重灼伤
        • R22 Harmful if swallowed 吞咽有害
        • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
          Storage condition Moisture Sensitive 对湿度敏感,储存温度:2-8°C Store at 5°C 储存温度2-8°C,充氩气保存 储存温度2-8°C
          Hazard Codes F,C
          Hazard Class4.1/8
        • 硅烷化剂。有机合成中作为羟基保护剂,衍生化试剂用于分析和制备。保护叔醇类。与醇类反应形成硅醚。测定胆固醇衍生物的构象。合成前列腺素,某些抗生素、降血脂药洛弗斯汀(Lovastatin)和新弗斯汀(Simvastatin)的辅助原料。
        • {ALF} Reagent for silylation of hydroxyl functions (see Appendix 4), giving silyl ethers more stable to aqueous
        • {uni_hamburg} Short: II/25D
        • {ALD} Merck: 14,10401
        • {ALF} Many other reagents have been used, including:
        • {TRC} Shen, H., et al.: J. Med. Chem., 53, 2666 (2010),
        • {ALF} Cleavage is generally effected with fluoride ion e.g. TBAF in an aprotic system: J. Am. Chem. Soc., 94, 6190 (1972), or KF with a phase-transfer catalyst: J. Am. Chem. Soc., 90, 4462, 4464 (1968); 96, 2250 (1974); J. Chem. Soc., Chem. Commun., 514 (1979).
        • {TRC} Qiang, L., et al.: Bioorg. Med. Chem. Lett., 20, 836 (2010),
        • {uni_hamburg} Short: EINECS
        • {ALF} Imidazole in DMF: J. Am. Chem. Soc., 94, 6190 (1972); Et3N - DMAP: Tetrahedron Lett., 99 (1979); Org. Synth. Coll., 9, 136 (1998); N-ethyldiisopropylamine: Tetrahedron Lett., 25, 227 (1984); 1,1,3,3-tetramethylguanidine: J. Org. Chem., 49, 4657 (1984); K2CO3 (phase-transfer): Synth. Commun., 11, 545 (1981); DBU - superior to imidazole for thiols, amines and carboxylic acids: Tetrahedron Lett., 26, 475 (1985).
        • {ALF} Reagent for silylation of hydroxyl functions (see Appendix 4), giving silyl ethers more stable to aqueous hydrolysis e.g. during work-up, than TMS. Various conditions have been used for the introduction of the group:
        • {ALF} Acidic ion-exchange resin: Tetrahedron Lett., 21, 137 (1980); NBS in DMSO: Synthesis, 234 (1980); BF3 etherate: Synth. Commun., 9, 295 (1979); FeCl3 or SnCl2 in acetonitrile: Synth. Commun., 20, 757 (1990); K 10 clay in aqueous methanol: J. Org. Chem. 61, 9026 (1996); DMSO-water at 90o; many other groups unaffected: Tetrahedron Lett., 38, 495 (1997). See also Pyridinium p-toluenesulfonate, A15708, and Triethyl­amine trihydrofluoride, L14417.
        • {ALD} Merck: 14,10401
        • Beilstein: 4,IV,4076
        • 18162-48-6 H28742 tert-Butylchlorodimethylsilane


          Mol. Formula(CH3)3CSi(CH3)2Cl
          Mol. Weight150.72
          Melting Point86-89
          Refractive indexn20/D 1.46
          Boiling Point125
          Flash Point7°(45°F)
          Appearance 白色固体。熔点86-89℃,沸点128℃。能与水、乙醇、有机酸或胺类缓慢反应。