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2',4'-Dihydroxyacetophenone 2,4-二羟基苯乙酮

规格: 97%

CAS: 89-84-9

产品编号: H26353

MDL: MFCD00002279

品牌: INFI

Chemical Name	2',4'-Dihydroxyacetophenone
CAS Number	89-84-9
Synonym	2',4'-Dihydroxyacetophenone {LY} 2',4'-Dihydroxyacetophenone {} {LY} 2',4'-Dihydroxyacetophenone {} {} {LY} 2',4'-Dihydroxyacetophenone {} {} {} {LY} 2',4'-Dihydroxyacetophenone {} {} {} {} {LY} 2',4'-Dihydroxyacetophenone {} {} {} {} {} {LY} 2',4'-Dihydroxyacetophenone {} {} {} {} {} {} {LY} 2',4'-Dihydroxyacetophenone {} {} {} {} {} {} {} {LY} 2',4'-Dihydroxyacetophenone {} {} {} {} {} {} {} {} {LY} 2',4'-Dihydroxyacetophenone {} {} {} {} {} {} {} {} {} {LY} 2',4'-Dihydroxyacetophenone {} {} {} {} {} {} {} {} {} {} {LY} 2',4'-Dihydroxyacetophenone {} {} {} {} {} {} {} {} {} {} {} {LY} 2',4'-Dihydroxyacetophenone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2',4'-Dihydroxyacetophenone {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2',4'-Dihydroxyacetophenone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2',4'-Dihydroxyacetophenone {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2',4'-Dihydroxyacetophenone {} {} {} {} {} {} {} {}
EC Number	201-945-3
Beilstein Registry Number	1282505
MDL Number	MFCD00002279
Merck Number	8140
PubChem Substance ID	87567215
Reaxys-RN	1282505
Chemical Name Translation	2,4-二羟基苯乙酮
Wiswesser Line Notation	QR CQ DV1
LabNetwork Molecule ID	LN00008658
InChI	InChI=1S/C8H8O3/c1-5(9)7-3-2-6(10)4-8(7)11/h2-4,10-11H,1H3
Canonical SMILES	CC(C1=CC=C(O)C=C1O)=O

GHS Symbol

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 2830 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   IHFCAY Industrial Hygiene Foundation of America, Chemical and Toxicological
   Series, Bulletin. (Pittsburgh, PA)  1947-69.  Volume(issue)/page/year:
   6,1,1967

TYPE OF TEST            : TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE       : Subcutaneous
SPECIES OBSERVED        : Rodent - rat
DOSE                    : 20 mg/kg
SEX/DURATION            : female 4 day(s) pre-mating
TOXIC EFFECTS :
   Reproductive - Maternal Effects - ovaries, fallopian tubes
   Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
   JSICAZ Journal of Scientific and Industrial Research, Section C: Biological
   Sciences.  (New Delhi, India)  V.14-21, 1955-62.  For publisher information,
   see IJEBA6.  Volume(issue)/page/year: 19,264,1960

Signal word	Danger
WGK Germany	2
Safety Statements
S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见； S36 Wear suitable protective clothing 穿戴适当的防护服；
Risk Statements
R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性 R37/38 Irritating to respiratory system and skin 对呼吸系统和皮肤有刺激性 R41 Risk of serious damage to eyes 有严重损伤眼睛的危险
Precautionary statements
P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。 P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。 P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。 P302+P350 P302+P352+P332+P313+P362+P364 P305+P351+P338 P305+P351+P338+P310 P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。 P332+P313 P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用
RTECS	AM7525000
Storage condition	2-8°C, stored under nitrogen {LY} 2-8°C, stored under nitrogen Moisture Sensitive {} {LY} 2-8°C, stored under nitrogen {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {} {} {} {} {} {} {} {} {} {} {LY} 2-8°C, stored under nitrogen {} {} {} {} {} {}
Hazard statements
H315 Causes skin irritation 会刺激皮肤 H318 Causes serious eye damage 严重伤害眼睛 H335 May cause respiratory irritation 可能导致呼吸道刺激 H303 May be harmfully swallowed 吞食可能有害
Personal Protective Equipment	dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes	Xi

用作有机合成中间体。医药工业用于制冠心病药乙氧黄酮等。

{ALD} Merck: 14,8140

Beilstein:8,266

{uni_hamburg} Short: EINECS

{uni_hamburg} Short: III/35E

{uni_hamburg} Short: III/38B

{ALF} The position of O-alkylation can be varied by suitable choice of reagent. Thus, NaH in DMSO followed by MeI gives predominantly the 2-alkylated product, whereas Li2CO3 in DMF favors 4-alkylation. The latter is a fairly general method for the alkylation of phenols, thiophenols and ß-diketones with pKa less than about 8: Synth. Commun., 18, 1379 (1988).

{MCE} [1]. Li XJ, et al. Bioactive metabolites from biotransformation of paeonol by the white-rot basidiomycete Coriolus versicolor. Nat Prod Commun. 2011 Aug;6(8):1129-30.

89-84-9 H26353 2',4'-Dihydroxyacetophenone 2,4-二羟基苯乙酮

化学属性

Mol. Formula	C8H8O3
Mol. Weight	152.149
Density	1.18
Melting Point	143-145°C
TSCA	Yes
Boiling Point	234.6 °C at 760 mmHg
Appearance	针状或叶状结晶。熔点147℃，相对密度1.180。在水中渐渐分解。溶于热醇、吡啶及冰醋酸中，几乎不溶于醚、苯和氯仿。与氯化铁作用显红色。

*以上化合物性质及应用等信息仅供参考

手性催化剂及配体

合成砌块

医药中间体

2',4'-Dihydroxyacetophenone 2,4-二羟基苯乙酮

规格: 97%

化学属性

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