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Phenylacetylene 苯乙炔

规格: 97%

CAS: 536-74-3

产品编号: H19625

MDL: MFCD00008570

品牌: INFI

Chemical Name	Phenylacetylene
MDL Number	MFCD00008570
CAS Number	536-74-3
Synonym	Benzene,ethynyl- Ethynylbenzene ethynylbenzene phenyl-acetylene phenylacetylene phenylethyne
PubChem Substance ID	10821
EC Number	208-645-1
Beilstein Registry Number	5,511
Merck Number	3861
Chemical Name Translation	苯乙炔
Reaxys-RN	605461
Wiswesser Line Notation	1UU1R
LabNetwork Molecule ID	LN00220511
InChI	InChI=1S/C8H6/c1-2-8-6-4-3-5-7-8/h1,3-7H

GHS Symbol

TYPE OF TEST            : LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE       : Intravenous
SPECIES OBSERVED        : Rodent - mouse
DOSE/DURATION           : 100 mg/kg
TOXIC EFFECTS :
   Details of toxic effects not reported other than lethal dose value
REFERENCE :
   CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems
   Laboratory, NIOSH Exchange Chemicals.  (Aberdeen Proving Ground, MD 21010)
   Volume(issue)/page/year: NX#04866

TYPE OF TEST            : LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE       : Oral
SPECIES OBSERVED        : Rodent - rat
DOSE/DURATION           : 10 mL/kg
TOXIC EFFECTS :
   Lungs, Thorax, or Respiration - fibrosis, focal (pneumoconiosis)
   Lungs, Thorax, or Respiration - acute pulmonary edema
   Blood - hemorrhage
REFERENCE :
   AMIHAB AMA Archives of Industrial Health.  (Chicago, IL)  V.11-21, 1955-60.
   For publisher information, see AEHLAU.  Volume(issue)/page/year: 19,403,1959

WGK Germany	3
RTECS	DA0780000
Packing Group	III
UN Number	3295
Risk Statements
R10 Flammable 易燃 R36/37 Irritating to eyes and respiratory system 对眼睛和呼吸系统有刺激性 R65 Harmful: may cause lung damage if swallowed 若吞咽可能伤害肺部器官
Safety Statements
S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护； S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见； S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟； S45 In case of accident or if you feel unwell seek medical advice immediately (show the label where possible) 发生事故时或感觉不适时，立即求医（可能时出示标签）；
Storage condition	0-10 0-10°C 2-8°C Light Sensitive 储存温度2-8℃ 对光敏感，2-8°C 避光保存
Hazard statements
H226 Flammable liquid and vapour 易燃液体和蒸气 H304 May be fatal if swallowed and enters airways 吞食和进入呼吸道可能致命 H315 Causes skin irritation 会刺激皮肤 H319 Causes serious eye irritation 严重刺激眼睛 H335 May cause respiratory irritation 可能导致呼吸道刺激 H351 Suspected of causing cancer 怀疑致癌
Personal Protective Equipment	Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Precautionary statements
P201 Obtain special instructions before use. 使用前获取专门指示。 P202 Do not handle until all safety precautions have been read and understood. 已阅读并理解所有的安全预防措施之前，切勿操作。 P203 P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。 P233 Keep container tightly closed. ?保持容器密闭。 P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。 P241 Use explosion-proof electrical/ventilating/lighting/…/equipment. 使用防爆电气/通风/照明/ .../设备。 P241+P242+P243 P242 Use only non-sparking tools. 只能使用无火花工具。 P243 Take precautionary measures against static discharge. 采取预防措施，防止静电放电。 P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。 P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。 P264+P265 P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。 P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。 P281 Use personal protective equipment as required. 使用所需的个人防护装备。 P301+P310 P301+P310+P331 P301+P316 P301+P330+P331 P302+P352 P302+P352+P332+P313+P362+P364 P303+P361+P353 P304+P340 P305+P351+P338 P305+P351+P338+P337+P313 P308+P313 P312 Call a POISON CENTER or doctor/physician if you feel unwell. 如果你感觉不适，呼叫解毒中心或医生/医师。 P318 P319 P321 Specific treatment (see … on this label). 具体治疗（见本标签上的）。 P331 Do NOT induce vomiting.. 不要催吐。 P332+P313 P332+P317 P337+P313 P337+P317 P362 Take off contaminated clothing and wash before reuse. 脱掉污染的衣服，清洗后方可重新使用 P362+P364 P370+P378 P403+P233 P403+P235 P405 Store locked up. 上锁保管。 P501 Dispose of contents/container to..… 处理内容物/容器.....
Signal word
Hazard Codes
Hazard Class	3
Warnings	危化品目录(2015)
Restrict	-

用于有机合成。

{ALF} For conversion to the Grignard with ethylmagnesium bromide, and subsequent Cu-catalyzed coupling with allyl bromide, see: Org. Synth. Coll., 6, 925 (1988).

{ALF} For cyanation with CuCN in the presence of TMS chloride and NaI, see: Tetrahedron Lett., 34, 591 (1993).

{ALF} Glaser oxidative coupling by Cu(OAc)2 in pyridine gives diphenylbuta-1,3-diyne: Org. Synth. Coll., 5, 499 (1973).

{ALD} Merck:14,3861

Beilstein:5,511

{ALF} Dimetallation can be accomplished with a 2:1 molar mixture of n-BuLi and KO-t-Bu in THF, the second metallation occurring specifically at the ortho-position. Thus, the bis(TMS)-derivative can be prepared in excellent yield: J. Org. Chem., 55, 1311 (1990).

{ALD} Merck:14,3861

{ALF} For preparation of the cuprate and references for coupling with aryl halides to give diarylacetylenes, see: Org. Synth. Coll., 6, 916 (1988).

{ALF} Conversion to the 1-bromoalkyne has been described: Org. Synth. Coll., 5, 921 (1973). For an improved phase-transfer method, using NaBr/NaOCl, see: J. Org. Chem., 57, 4555 (1992).

化学属性

Mol. Formula	C8H6
Mol. Weight	102
Refractive index	1.5470 to 1.5510
Boiling Point	142°C
Vapor Pressure	17.6 mmHg ( 37.7 °C)
Density	0.91
Flash Point	27°C(lit.)
TSCA	Yes
Melting Point	-44.8°C
Solubility	不溶于水，可混溶于醇、醚等多数有机溶剂。
Stability	对热和光线敏感
pH	-:A
Danger-Level	-
Redox	-

*以上化合物性质及应用等信息仅供参考

手性催化剂及配体

合成砌块

医药中间体

Phenylacetylene 苯乙炔

规格: 97%

化学属性

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