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Chloromethyltrimethylsilane 氯甲基三甲基硅烷

规格: 98%

CAS: 2344-80-1

产品编号: H17904

MDL: MFCD00000878

品牌: INFI

有机硅系列

有机硅烷类化合物主要应用在有机合成及有机硅材料领域。在有机合成中，硅烷作为羟基保护基大量存在，如三甲基氯硅烷，TBSCI,有时作为一个合成子载体存在，如乙烯基三甲基硅烷，烯丙基三甲基硅烷，六甲基二硅硫烷等，从而实现相应的官能团化反应。有机硅材料领域有硅烷偶联剂、硅油（硅脂、硅乳液、硅表面活性剂）、高温硫化硅橡胶、液体硅橡胶、硅树脂、封端剂，含硅复合共聚物等。

应用介绍及参考文献

1 .如乙烯基三甲基硅烷作为一个“乙烯”合成子，用于3+2环加成反应，应用于有机合成过程中

参考文献:Vinyltrimethylsilane, Glenn J. Fegley Gerald L. Larson, Encyclopedia of Reagents for Organic Synthesis, 2008.

2.如烯丙基三甲基硅烷，作为一个烯丙基化试剂，应用于艾日布林或者前列素类似物的合成中。

TiCl3（OiPr）

参考文献：W020050118565, WO2019102490

参考文献：Gary A. Sulikowski et al Org. Lett. 2019, 21, 10048-10051

3.作为聚合引发剂，或者烯姪共聚物，参与烯姪聚合，形成功能性有机硅材料，如耐水性硅胶粘合剂，修饰聚氟乙烯等

技术优势

产品纯度高，具有百公斤生产能力

Chemical Name	Chloromethyltrimethylsilane
Synonym	氯甲基三甲硅 chloromethyl-trimethyl-silane (氯甲基)三甲基硅烷 (CH3)3SiCH2Cl Chlormethyl-trimethylsilan CC3285 trimethylsilyl chloride (TRIMETHYLSILYL)METHYL CHLORIDE Trimethylsilyl-chlormethan Trimethyl(chloromethyl)silane SILANE CMM3 氯甲基三甲基硅烷 Trimethylsilylmethyl chloride 氯甲基三甲硅烷 (Chlormethyl)trimethylsilan 三甲基氯甲基硅烷 (Chlormethyl)-trimethylsilan chlormethyltrimethylsilan
MDL Number	MFCD00000878
CAS Number	2344-80-1
EC Number	219-058-5
Beilstein Registry Number	906705
PubChem Substance ID	87565921
Reaxys-RN	906705
Chemical Name Translation	氯甲基三甲基硅烷
InChIKey	OOCUOKHIVGWCTJ-UHFFFAOYSA-N
LabNetwork Molecule ID	LN01268178
InChI	InChI=1S/C4H11ClSi/c1-6(2,3)4-5/h4H2,1-3H3

GHS Symbol

Packing Group	II
UN Number	1993
Risk Statements
R34 Causes burns 会导致灼伤 R11 Highly flammable 非常易燃 R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
Safety Statements
S29 Do not empty into drains 不要排入下水道； S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后，立即用大量水冲洗并征求医生意见； S16 Keep away from sources of ignition - No smoking 远离火源，禁止吸烟； S36 Wear suitable protective clothing 穿戴适当的防护服； S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾； S33 Take precautionary measures against static discharges 对静电采取预防措施； S37 Wear suitable gloves 戴适当手套； S9 Keep container in a well-ventilated place 保持容器在通风良好的场所； S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护；
Storage condition	Moisture Sensitive Flammables area 对湿度敏感
WGK Germany	3
Hazard statements
H315 Causes skin irritation 会刺激皮肤 H335 May cause respiratory irritation 可能导致呼吸道刺激 H225 Highly flammable liquid and vapour 高度易燃液体和蒸气 H319 Causes serious eye irritation 严重刺激眼睛
Personal Protective Equipment	Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
Precautionary statements
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。 P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。 P305+P351+P338 P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。 P501 Dispose of contents/container to..… 处理内容物/容器..... P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。 P303+P361+P353+P310+ P305+P351+P338+P310 P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。 P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。 P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。 P301+P330+P331+P310 P303+P361+P353 P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。 P370+P378 P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西，喝水或吸烟。 P403+P235 P301+P330+P331 P304+P340+P312 P304+P340+P310
Signal word
Hazard Codes	F,Xi,C
Hazard Class	3/8
Warnings	危化品目录(2015)

{ALD} Beilstein:4(3)1844

{ALF} For a review of the chemistry of chloromethyltrimethylsilane, see: Synthesis, 717 (1985).

{ALF} Metallation gives useful precursors of various organosilicon compounds. For use of the Grignard in the olefination of ketones, see: J. Org. Chem., 39, 3264 (1974); 52, 281 (1987). For Ni-catalyzed reaction of the Grignard with allylic dithioacetals, see: J. Org. Chem., 53, 5582 (1988); Org. Synth. Coll., 9, 727 (1998); for an example with reaction scheme, see trans-Cinnamaldehyde, A14689.

{uni_hamburg} Short: III/20a

{uni_hamburg} Short: III/35F

{ALF} Treatment with s-BuLi at -78o gives ɑ-lithio-ɑ-chloromethyltrimethylsilane which reacts with aldehydes and ketones to give ɑß-epoxy silanes, readily hydrolyzed to homologated aldehydes: Tetrahedron, 39, 867 (1983):

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2344-80-1 H17904 Chloromethyltrimethylsilane
氯甲基三甲基硅烷

化学属性

Mol. Formula	C4H11ClSi
Mol. Weight	122.67
Density	0.879
Refractive index	1.4160 to 1.4180
Flash Point	-2°C(lit.)
TSCA	Yes
Boiling Point	98-99
Vapor Pressure	~25 mmHg ( 20 °C)
Solubility	溶于部分有机溶剂。
Melting Point	<0°C
Stability	对湿度敏感

手性催化剂及配体

合成砌块

医药中间体

Chloromethyltrimethylsilane 氯甲基三甲基硅烷

规格: 98%

有机硅系列

化学属性

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