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Chloromethyltrimethylsilane 氯甲基三甲基硅烷

规格: 98%
CAS: 2344-80-1
产品编号: H17904
MDL: MFCD00000878
品牌: INFI

有机硅烷类化合物主要应用在有机合成及有机硅材料领域。在有机合成中,硅烷作为羟基 保护基大量存在,如三甲基氯硅烷,TBSCI,有时作为一个合成子载体存在,如乙烯基三甲基 硅烷,烯丙基三甲基硅烷,六甲基二硅硫烷等,从而实现相应的官能团化反应。有机硅材料领域有硅烷偶联剂、硅油(硅脂、硅乳液、硅表面活性剂)、高温硫化硅橡胶、液体硅橡胶、硅 树脂、封端剂,含硅复合共聚物等。

应用介绍及参考文献

1 .如乙烯基三甲基硅烷作为一个“乙”合成子,用于3+2环加成反应,应用于有机合成过程中

  

参考文献:Vinyltrimethylsilane, Glenn J. Fegley Gerald L. Larson, Encyclopedia of Reagents for Organic Synthesis, 2008.


2.如烯丙基三甲基硅烷,作为一个烯丙基化试剂,应用于艾日布林或者前列素类似物的合成中。

TiCl3(OiPr)

参考文献:W020050118565, WO2019102490


参考文献:Gary A. Sulikowski et al Org. Lett. 2019, 21, 10048-10051


参考文献:Gary A. Sulikowski et al Org. Lett. 2019, 21, 10048-10051

3.作为聚合引发剂,或者烯姪共聚物,参与烯姪聚合,形成功能性有机硅材料,如耐水性硅胶 粘合剂,修饰聚氟乙烯等

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Chemical NameChloromethyltrimethylsilane
Synonym 氯甲基三甲硅 chloromethyl-trimethyl-silane (氯甲基)三甲基硅烷 (CH3)3SiCH2Cl Chlormethyl-trimethylsilan CC3285 trimethylsilyl chloride (TRIMETHYLSILYL)METHYL CHLORIDE Trimethylsilyl-chlormethan Trimethyl(chloromethyl)silane SILANE CMM3 氯甲基三甲基硅烷 Trimethylsilylmethyl chloride 氯甲基三甲硅烷 (Chlormethyl)trimethylsilan 三甲基氯甲基硅烷 (Chlormethyl)-trimethylsilan chlormethyltrimethylsilan
MDL NumberMFCD00000878
CAS Number2344-80-1
EC Number219-058-5
Beilstein Registry Number906705
PubChem Substance ID87565921
Reaxys-RN906705
Chemical Name Translation氯甲基三甲基硅烷
InChIKeyOOCUOKHIVGWCTJ-UHFFFAOYSA-N
LabNetwork Molecule IDLN01268178
InChIInChI=1S/C4H11ClSi/c1-6(2,3)4-5/h4H2,1-3H3
GHS Symbol
Packing GroupII
UN Number 1993
Risk Statements
  • R34 Causes burns 会导致灼伤
  • R11 Highly flammable 非常易燃
  • R36/37/38 Irritating to eyes, respiratory system and skin 对眼睛、呼吸系统和皮肤有刺激性
    Safety Statements
    • S29 Do not empty into drains 不要排入下水道;
    • S26 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 眼睛接触后,立即用大量水冲洗并征求医生意见;
    • S16 Keep away from sources of ignition - No smoking 远离火源,禁止吸烟;
    • S36 Wear suitable protective clothing 穿戴适当的防护服;
    • S23 Do not breathe gas/fumes/vapour/spray (appropriate wording to be specified by the manufacturer) 不要吸入气体/烟雾/蒸汽/喷雾;
    • S33 Take precautionary measures against static discharges 对静电采取预防措施;
    • S37 Wear suitable gloves 戴适当手套;
    • S9 Keep container in a well-ventilated place 保持容器在通风良好的场所;
    • S36/37/39 Wear suitable protective clothing, gloves and eye/face protection 穿戴适当的防护服、手套和眼睛/面保护;
      Storage condition Moisture Sensitive Flammables area 对湿度敏感
      WGK Germany3
      Hazard statements
      • H315 Causes skin irritation 会刺激皮肤
      • H335 May cause respiratory irritation 可能导致呼吸道刺激
      • H225 Highly flammable liquid and vapour 高度易燃液体和蒸气
      • H319 Causes serious eye irritation 严重刺激眼睛
        Personal Protective Equipment Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter
        Precautionary statements
        • P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking. 远离热源/火花/明火/热的表面。——禁止吸烟。
        • P261 Avoid breathing dust/fume/gas/mist/vapours/spray. 避免吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
        • P305+P351+P338
        • P271 Use only outdoors or in a well-ventilated area.? 只能在室外或通风良好的地方使用。
        • P501 Dispose of contents/container to..… 处理内容物/容器.....
        • P260 Do not breathe dust/fume/gas/mist/vapours/spray. 不要吸入粉尘/烟/气体/烟雾/蒸汽/喷雾。
        • P303+P361+P353+P310+
        • P305+P351+P338+P310
        • P310 Immediately call a POISON CENTER or doctor/physician. 立即呼救解毒中心或医生/医师。
        • P280 Wear protective gloves/protective clothing/eye protection/face protection. 戴防护手套/防护服/眼睛的保护物/面部保护物。
        • P264 Wash hands thoroughly after handling. 处理后要彻底洗净双手。
        • P301+P330+P331+P310
        • P303+P361+P353
        • P240 Ground/bond container and receiving equipment. 与地面接触/连接集装箱和接受设备。
        • P370+P378
        • P270 Do not eat, drink or smoke when using this product. 使用本产品时不要吃东西,喝水或吸烟。
        • P403+P235
        • P301+P330+P331
        • P304+P340+P312
        • P304+P340+P310
          Signal word
          Hazard Codes F,Xi,C
          Hazard Class3/8
          Warnings 危化品目录(2015)
        • {ALD} Beilstein:4(3)1844
        • {ALF} For a review of the chemistry of chloromethyltrimethylsilane, see: Synthesis, 717 (1985).
        • {ALF} Metallation gives useful precursors of various organosilicon compounds. For use of the Grignard in the olefination of ketones, see: J. Org. Chem., 39, 3264 (1974); 52, 281 (1987). For Ni-catalyzed reaction of the Grignard with allylic dithioacetals, see: J. Org. Chem., 53, 5582 (1988); Org. Synth. Coll., 9, 727 (1998); for an example with reaction scheme, see trans-Cinnamaldehyde, A14689.
        • {uni_hamburg} Short: III/20a
        • {uni_hamburg} Short: III/35F
        • {ALF} Treatment with s-BuLi at -78o gives ɑ-lithio-ɑ-chloromethyltrimethylsilane which reacts with aldehydes and ketones to give ɑß-epoxy silanes, readily hydrolyzed to homologated aldehydes: Tetrahedron, 39, 867 (1983):
        • {} {
        • 2344-80-1 H17904 Chloromethyltrimethylsilane
氯甲基三甲基硅烷

          化学属性

          Mol. FormulaC4H11ClSi
          Mol. Weight122.67
          Density0.879
          Refractive index1.4160 to 1.4180
          Flash Point-2°C(lit.)
          TSCAYes
          Boiling Point98-99
          Vapor Pressure~25 mmHg ( 20 °C)
          Solubility溶于部分有机溶剂。
          Melting Point<0°C
          Stability对湿度敏感